1. On Agility and Adaptability: "Agility is the ability to adapt and respond to change... agile organizations view change as an opportunity, not a threat." 2. On Diligence and Accuracy: "Quality is never an accident; it is always the result of intelligent effort." "Details create the big picture." 3. On Avoiding Slovenly Work: "Sloppiness breeds mediocrity; excellence begins in the small details."

https://greendaygh.github.io/Rstat2020/

The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors and is frequently deregulated in cancer. Here we report co-crystal structures of a complex of truncated mTOR and mammalian lethal with SEC13 protein 8 (mLST8) with an ATP transition state mimic and with ATP-site inhibitors. The structures ..

Fluorogenic Chemogenetic Biosensors for Biological ImagingFluorescent chemogenetic biosensors based on natural fluorogens. (A) Chemical structure of the endogenous fluorogen biliverdin (BV). (B) iSplit: irreversible reconstitution of mIFP upon protein‐protein interaction allows covalent BV binding, thus fluorescence activation. (C) NIR‐GECO1: Conformational change of the calmodulin sensing modul..

- HOMO and LUMOHOMO stands for Highest Occupied Molecular Orbital, which means the highest energy level among the orbitals occupied by electrons. On the other hand, LUMO stands for Lowest Unoccupied Molecular Orbital, which means the lowest energy level among the orbitals that are not filled by electrons. These two can be easily found through a diagram.HOMO and LUMO are related to the color of t..

1. Immune Response and Immunophenotyping Objective: Understanding immune cell dynamics and responses, particularly in infection and inflammation. Application: Flow cytometry is used to identify different immune cell populations and analyze their surface markers. It helps track the behavior of T cells, B cells, and monocytes in various conditions. Example Article: "Flow cytometry-based identifica..