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Vibe coding tool has amplified the importance of creativity and planning —however, democratization of programming does not eliminate the need for deep technical skills. AI may assist in writing code, but when it comes to debugging complex errors, understanding the underlying logic, or scaling a system, high-level coding expertise remains essential.

1. WritersWriters are enzymes that add chemical modifications to RNA molecules. They establish the modification marks on RNA, such as methylation or acetylation.Examples of Writers:m6A Methyltransferases: Add m6A modifications.METTL3-METTL14 complex: Core m6A methyltransferase.WTAP: A cofactor that enhances m6A writing.m5C Writers:NSUN family proteins: Add m5C to tRNA, rRNA, and mRNA.Pseudouridi..

Types of Long-Term Injectable DDS:1. Microspheres and Nanoparticles:Mechanism: Biodegradable polymers (e.g., PLGA) encapsulate the drug, gradually releasing it as the polymer degrades.Applications: Hormones (like leuprolide), antipsychotics, and cancer therapies.2. Implants:Mechanism: Small rods or devices are surgically or subcutaneously implanted, slowly releasing drugs.Applications: Contracep..

→ The common point they emphasized is that science comes first.In the rapidly evolving biotechnology industry, open collaboration has become a cornerstone for innovation and advancement. Companies, research institutions, and startups are increasingly engaging in collaborative efforts to drive breakthroughs that would be challenging to achieve independently. While such partnerships involve variou..

How to Deliver an Effective TalkStarting the Talk1. Avoid Humor at the Start: Skip jokes to keep the beginning focused and professional.2. Set Expectations: Clearly outline what the audience will gain from your talk.3. Reinforce Key Points: Repeat your main ideas to ensure everyone fully understands them.4. Define Your Concept: Use a “fence” around your idea to distinguish it from others.5. Summ..

1. Start with a Hook Open with a compelling statistic, real-world example, or key question that highlights the importance of your research. This grabs attention and provides context. 2. Define Your Objective Clearly Clearly state your research question and objectives early on. Explain why your work is significant, especially in terms of potential real-world applications or contributions to the f..

Tumors: scRNA-seq has proven to be an invaluable tool in understanding the mechanisms behind tumor development. Its application in tumor analysis has shed light on previously overlooked or underappreciated cell populations. For instance, scRNA-seq studies of pancreatic ductal adenocarcinoma (PDA) highlighted the importance and heterogeneity of cancer-associated fibroblasts (CAFs). It was discove..

출처 : Nat Rev Bioengineering (2023) ■ Lipid Nanoparticles in the Development of Nucleic Acid Therapeutics Lipid nanoparticles (LNPs) are an FDA-approved delivery technology used for delivering siRNA to the liver and mRNA vaccines. During the COVID-19 pandemic, LNP-based mRNA vaccines played a crucial role in preventing and blocking infections, drawing significant attention to lipid nanoparticle d..