My Ántonia - Willa Cather 1. "Whatever we had missed, we possessed together the precious, the incommunicable past." 2. "She had that something which fires the imagination, could not be forgotten, would not be dismissed from thought." 3. "Antonia’s laughter was like the sunlight on the Nebraska plains." 4. "That is happiness; to be dissolved into something complete and great." 5. "The world was l..

The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors and is frequently deregulated in cancer. Here we report co-crystal structures of a complex of truncated mTOR and mammalian lethal with SEC13 protein 8 (mLST8) with an ATP transition state mimic and with ATP-site inhibitors. The structures ..

Fluorogenic Chemogenetic Biosensors for Biological ImagingFluorescent chemogenetic biosensors based on natural fluorogens. (A) Chemical structure of the endogenous fluorogen biliverdin (BV). (B) iSplit: irreversible reconstitution of mIFP upon protein‐protein interaction allows covalent BV binding, thus fluorescence activation. (C) NIR‐GECO1: Conformational change of the calmodulin sensing modul..

- HOMO and LUMOHOMO stands for Highest Occupied Molecular Orbital, which means the highest energy level among the orbitals occupied by electrons. On the other hand, LUMO stands for Lowest Unoccupied Molecular Orbital, which means the lowest energy level among the orbitals that are not filled by electrons. These two can be easily found through a diagram.HOMO and LUMO are related to the color of t..